Food Research Institute: CLA (conjugated linoleic acid) references

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References on Conjugated Linoleic Acid (CLA)
updated 6 October 2008

year of publication: | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | prior to 2000 |

2008
Analytical Methods	for detection of CLA and its isomers
Effect of Diet	and other conditions on CLA levels in animals and animal products
Food, CLA content
General Articles and Reviews	If review articles can fit into one other category, e.g. Food, then they are put into that category; if they cover material that would be in more than one category, then they will be here in "General"
Physiological Effects of CLA: ... in Human Studies; ... in Laboratory Animals, Companion Animals (pets); ... in Food/Farm Animals (ruminants, swine, poultry, fish); ... in Cell Cultures, In Vitro Studies	(includes fat/protein levels, anticarcinogenic effects, etc.):
Synthesis and Degradation of CLA	in vitro, microbial, plant

added 10/6/08

Botelho AP, Santos-Zago LF, de Oliveira AC. Conjugated linoleic acid supplementation modified the body composition and serum leptin levels in weaning rats. Archivos Latinoamericanos Nutricion 58(2):156-163 (2008).
Chaves AV, Stanford K, Dugan MER, Gibson LL, McAllister TA, Van Herk F, Benchaar C. Effects of cinnamaldehyde, garlic and juniper berry essential oils on rumen fermentation, blood metabolites, growth performance, and carcass characteristics of growing lambs. Livestock Sci. 117(2-3):215-224 (2008).
Kim YJ, Yoon YB. Effects of various levels of conjugated linoleic acid supplementation on the quality of chicken meat. Korean J. Food Sci. Anim. Res. 28(3):251-255 (2008).
Martin D, Muriel E, Gonzalez E, Viguera J, Ruiz J. Effect of dietary conjugated linoleic acid and monounsaturated fatty acids on productive, carcass and meat quality traits of pigs. Livestock Sci. 117(2-3):155-164 (2008).
Suksombat W, Chullanandana K. Effects of soybean oil or rumen protected conjugated linoleic acid supplementation on accumulation of conjugated linoleic acid in dairy cows' milk. Asian-Australian J. Anim. Sci. 21(9):1271-1277 (2008).
Sultana H, Ishida T, Shintaku T, Kanda S, Itabashi H. Effect of feeding Ca-salts of fatty acids from soybean oil and linseed oil on c9,t11-CLA production in ruminal fluid and milk of Holstein dairy cows. Asian-Australian J. Anin. Sci. 21(9):1262-1270 (2008).
Van QCD, Focant M, Deswysen D, Mignolet E, Turu C, Pottier I, Froidmont E, Larondelle Y. Influence of an increase in diet structure on milk conjugated linoleic acid content of cows fed extruded linseed. Animal 2(10):1538-1547 (2008).
Yee JK, Mao CS, Hummel HS, Lim S, Sugano S, Rehan VK, Xiao G, Lee WNP. Compartmentalization of stearoyl-coenzyme A desaturase 1 activity in HepG2 cells. J. Lipid Res. 49(10):2124-2134 (2008).
Zhao ZY, Wu TX, Tang HG, Zhang JZ. Influence of dietary conjugated linoleic acid on growth, fatty acid composition and hepatic lipogenesis in large yellow croaker (Pseudosciaena crocea R.). J. Zhejiang Univ. Sci. B 9(9):691-700 (2008).

added 9/26/08

Aricetti JA, Rotta PP, do Prado RM, Perotto D, Moletta JL, Matsushita M, do Prado IN. Carcass characteristics, chemical composition and fatty acid profile of Longissimus muscle of bulls and steers finished in a pasture system bulls and steers finished in pasture systems. Asian-Australasian J. Anim. Sci. 21(10):1441-1448 (2008).
Benedetti E, Galzio R, Cinque B, Biordi L, D'Amico MA, D'Angelo B, Laurenti G, Ricci A, Festuccia C, Cifone MG, Lombardi D, Cimini A. Biomolecular characterization of human glioblastoma cells in primary cultures: Differentiating and antiangiogenic effects of natural and synthetic PPAR gamma agonists. J. Cell. Physiol. 217(1):93-102 (2008).
Chen BL, Guo Z, Let MB, Lue BM, Xu XB. Preparation of CLA ascorbyl ester with improved volumetric productivity by an ionic liquid-based reaction system. Organic Biomolecular Chem. 6(17):3196-3201 (2008).
do Prado IN, Aricetti JA, Rotta PP, do Prado RM, Perotto D, Visentainer JV, Matsushita M. Carcass characteristics, chemical composition and fatty acid profile of the Longissimus muscle of bulls (Bos taurus indicus vs. Bos taurus taurus) finished in pasture systems. Asian-Australasian J. Anim. Sci. 21(10):1449-1457 (2008).
Ferramosca A, Savy V, Conte L, Zara V. Dietary combination of conjugated linoleic acid (CLA) and pine nut oil prevents CLA-induced fatty liver in mice. J. Agric. Food Chem. 56(17):8148-8158 (2008).
Jain VP, Tokle T, Kelkar S, Proctor A. Effect of the degree of processing on soy oil conjugated linoleic acid yields. J. Agric. Food Chem. 56(17):8174-8178 (2008).
Lee MRF, Tweed JKS. Isomerisation of cis-9 trans-11 conjugated linoleic acid (CLA) to trans-9 trans-11 CLA during acidic methylation can be avoided by a rapid base catalysed methylation of milk fat. J. Dairy Res. 75(3):354-356 (2008).
Leiber F, Meier JS, Burger B, Wettstein HR, Kreuzer M, Hatt JM, Clauss M. Significance of coprophagy for the fatty acid profile in body tissues of rabbits fed different diets. Lipids 43(9):853-865 (2008).
Marounek M, Skrivanova V, Vyborna A, Duskova D. Performance and tissue fatty acid profiles in veal calves fed diets supplemented with conjugated linoleic acids. Arch. Anim. Nutr. 62(5):366-376 (2008).
Ogborn MR, Nitschmann E, Goldberg A, Bankovic-Calic N, Weiler HA, Aukema HM. Dietary conjugated linoleic acid renal benefits and possible toxicity vary with isomer, dose and gender in rat polycystic kidney disease. Lipids 43(9):783-791 (2008).
Suksombat W, Chullanandana K. Effects of soybean oil or whole cotton seed addition on accumulation of conjugated linoleic acid in beef of fattening BrahmanxThai-Native cattle. Asian-Australasian J. Anim. Sci. 21(10):1458-1465 (2008).
Tsiplakou E, Zervas G. The effect of dietary inclusion of olive tree leaves and grape marc on the content of conjugated linoleic acid and vaccenic acid in the milk of dairy sheep and goats. J. Dairy Res. 75(3):270-278 (2008).
Zunong M, Hanada M, Aibibula Y, Okamoto M, Tanaka K. Variations in conjugated linoleic acid concentrations in cows milk, depending on feeding systems in different seasons. Asian-Australasian J. Anim. Sci. 21(10):1466-1472 (2008).

added 9/19/08

Banu J, Bhattacharya A, Rahman M, Fernandes G. Beneficial effects of conjugated linoleic acid and exercise on bone of middle-aged female mice. J. Bone Mineral Metab. 26(5):436-445 (2008).
Durmic Z, McSweeney CS, Kemp GW, Hutton P, Wallace RJ, Vercoe PE. Australian plants with potential to inhibit bacteria and processes involved in ruminal biohydrogenation of fatty acids. Anim. Feed Sci. Technol. 145(1-4):271-284 (2008).
Fagali N, Catala A. Antioxidant activity of conjugated linoleic acid isomers, linoleic acid and its methyl ester determined by photoemission and DPPH center dot techniques. Biophysical Chem. 137(1):56-62 (2008).
Gervais R, Chouinard PY. Effects of intravenous infusion of conjugated diene 18 : 3 isomers on milk fat synthesis in lactating dairy cows. J. Dairy Sci. 91(9):3568-3578 (2008).
Lock AL, Rovai M, Gipson TA, de Veth MJ, Bauman DE. A conjugated linoleic acid supplement containing trans-10, cis-12 conjugated linoleic acid reduces milk fat synthesis in lactating goats. J. Dairy Sci. 91(9):3291-3299 (2008).
Lourenco M, Van Ranst G, Vlaeminck B, De Smet S, Fievez V. Influence of different dietary forages on the fatty acid composition of rumen digesta as well as ruminant meat and milk. Anim. Feed Sci. Technol. 145(1-4):418-437 (2008).
Mel'uchova B, Blasko J, Kubinec R, Gorova R, Dubravska J, Margetin M, Sojak L. Seasonal variations in fatty acid composition of pasture forage plants and CLA content in ewe milk fat. Small Ruminant Res. 78(1-3):56-65 (2008).
Nie L, Ren Y, Janakiraman A, Smith S, Schulz H. A novel paradigm of fatty acid beta-oxidation exemplified by the thioesterase-dependent partial degradation of conjugated linoleic acid that fully supports growth of Escherichia coli. Biochemistry 47(36):9618-9626 (2008).
Ringseis R, Schulz N, Saal D, Eder K . Troglitazone but not conjugated linoleic acid reduces gene expression and activity of matrix-metalloproteinases-2 and -9 in PMA-differentiated THP-1 macrophages. J. Nutr. Biochem. 19(9):594-603 (2008).

added 9/15/08

Patterson R, Connor ML, Krause DO, Nyachoti CM. Response of piglets weaned from sows fed diets supplemented with conjugated linoleic acid (CLA) to an Escherichia coli K88(+) oral challenge. Animal 2(9):1303-1311 (2008).
Yamasaki M, Tachibana H, Yamada A, Ochi Y, Madhyastha H, Nishiyama K, Yamada K. Oleic acid prevents apoptotic cell death induced by trans10, cis12 isomer of conjugated linoleic acid via p38 MAP kinase dependent pathway. In Vitro Cellular Developmental Biol. Animal 44(7):290-294 (2008).

2008

Analytical Methods return to top

Blasko J, Kubinec R, Pavikova E, Krupcik J, Sojak L. On the chemometric deconvolution of gas chromatographically unseparated trans-7,cis-9, cis-9,trans-11 and trans-8,cis-10 octadecadienoic acid isomers in ewe and cow milks. J. Food Nutr. Res. 47(1):29-36 (2008).
Kramer JKG, Hernandez M, Cruz-Hernandez C, Kraft J, Dugan MER. Combining results of two GC separations partly achieves determination of all cis and trans 16 : 1, 18 : 1, 18 : 2 and 18 : 3 except CLA isomers of milk fat as demonstrated using ag-ion SPE fractionation. Lipids 43(3):259-273 (2008).
Pajunen TI, Koskela H, Hase T, and Hopia A. NMR properties of conjugated linoleic acid (CLA) methyl ester hydroperoxides. Chem. Phys. Lipids 154:105-114 (2008).
Schripsema J. Comprehensive analysis of polar and apolar constituents of butter and margarine by nuclear magnetic resonance, reflecting quality and production processes. (Review.) J. Agric. Food Chem. 56(8):2547-2552 (2008).
Tokusoglu O. Conjugated linoleic acid (CLA). Cis 9, trans11 and trans 10, cis12 isomer detection in crude and refined corn oils by capillary GC. Grasas Aceites 59(2):146-151 (2008).
Uehara H, Suganuma T, Negishi S, Uda Y, Furukawa Y, Ueno S, Sato K. Physical properties of two isomers of conjugated linoleic acid. J. Am. Oil Chem. Sco. 85(1):29-36 (2008).

Effects of Diet and Other Conditions on CLA in Animals and Animal Products return to top

AbuGhazaleh AA. Effect of fish oil and sunflower oil supplementation on milk conjugated linoleic acid content for grazing dairy cows. Anim. Feed Sci. Technol. 141(3-4):220-232 (2008).
AlZahal O, Odongo NE, Mutsvangwa T, Or-Rashid MM, Duffield TF, Bagg R, Dick P, Vessie G, McBride BW. Effects of monensin and dietary soybean oil on milk fat percentage and milk fatty acid profile in lactating dairy cows. J. Dairy Sci. 91(3):1166-1174 (2008).
Aricetti JA, Rotta PP, do Prado RM, Perotto D, Moletta JL, Matsushita M, do Prado IN. Carcass characteristics, chemical composition and fatty acid profile of Longissimus muscle of bulls and steers finished in a pasture system bulls and steers finished in pasture systems. Asian-Australasian J. Anim. Sci. 21(10):1441-1448 (2008).
Avondo M, Bonanno A, Pagano RI, Valenti B, Di Grigoli A, Alicata ML, Galofaro V, Pennisi P. Milk quality as affected by grazing time of day in Mediterranean goats. J. Dairy Res. 75(1):48-54 (2008).
Baltusnikiene A, Bartkeviciute Z, Cernauskiene J Fatty acids content and composition of milk fat from cows consuming pasture and total mixed ration. Veterinarija Zootechnika 42(64):28-33 (2008).
Bee G, Jacot S, Guex G, Biolley C. Effects of two supplementation levels of linseed combined with CLA or tallow on meat quality traits and fatty acid profile of adipose and different muscle tissues in slaughter pigs. Animal 2(5):800-811 (2008).
Bernard L, Leroux C, Chilliard Y. Expression and nutritional regulation of lipogenic genes in the ruminant lactating mammary gland. Bioactive Components Milk 606:67-108 (2008).
Bharathan M, Schingoethe DJ, Hippen AR, Kalscheur KF, Gibson ML, Karges K. Conjugated linoleic acid increases in milk from cows fed condensed corn distillers solubles and fish oil. J. Dairy Sci. 92(7):2796-2807 (2008).
Bisig W, Collomb M, Butikofer U, et al. Seasonal variation of fatty acid composition in Swiss mountain's milk. Agrarforschung 15(1):38-43 (2008).
Bouattour MA, Casals R, Albanell E, Such X, Caja G. Feeding soybean oil to dairy goats increases conjugated linoleic acid in milk. J. Dairy Sci. 91(6):2399-2407 (2008).
Butler G, Nielsen JH, Slots T, Seal C, Eyre MD, Sanderson R, Leifert C. Fatty acid and fat-soluble antioxidant concentrations in milk from high- and low-input conventional and organic systems: seasonal variation. J. Sci. Food Agric. 88(8):1431-1441 (2008).
Brown W, AbuGhazaleh AA, Ibrahim SA. Milk conjugated linoleic acid response to fish oil and linseed oil supplementation of grazing dairy cows. Asian-Australasian J. Anim. Sci. 21(5):663-670 (2008).
Chantaprasarn N, Wanapat M. Effects of sunflower oil supplementation in cassava hay based-diets for lactating dairy cows. Asian-Australiasian J. Anim. Sci. 21(1):42-50 (2008).
Chaves AV, Stanford K, Dugan MER, Gibson LL, McAllister TA, Van Herk F, Benchaar C. Effects of cinnamaldehyde, garlic and juniper berry essential oils on rumen fermentation, blood metabolites, growth performance, and carcass characteristics of growing lambs. Livestock Sci. 117(2-3):215-224 (2008).
Chen P, Ji P, Li SL. Effects of feeding extruded soybean, ground canola seed and whole cottonseed on ruminal fermentation, performance and milk fatty acid profile in early lactation-dairy cows. Asian-Australiasian J. Anim. Sci. 21(2):204-213 (2008).
De Noni I, Battelli G. Terpenes and fatty acid profiles of milk fat and "Bitto" cheese as affected by transhumance of cows on different mountain pastures. Food Chem. 109(2):299-309 (2008).
Descalzo AM, Sancho AM. A review of natural antioxidants and their effects on oxidative status, odor and quality of fresh beef produced in Argentina. (Review.) Meat Sci. 79(3):423-436 (2008).
Doepel L, Toronchuk GP, Crowe JRE. The effect of dietary linola oil on CLA and other fatty acids in bovine milk. Can. J. Anim. Sci. 88(2):321-324 (2008).
do Prado IN, Aricetti JA, Rotta PP, do Prado RM, Perotto D, Visentainer JV, Matsushita M. Carcass characteristics, chemical composition and fatty acid profile of the Longissimus muscle of bulls (Bos taurus indicus vs. Bos taurus taurus) finished in pasture systems. Asian-Australasian J. Anim. Sci. 21(10):1449-1457 (2008).
Duffield TF, Rabiee AR, Lean IJ. A meta-analysis of the impact of monensin in lactating dairy cattle. Part 2. Production effects. J. Dairy Sci. 91(4):1347-1360 (2008).
Dunshea FR, Walker GP, Ostrowska E, Doyle PT. Seasonal variation in the concentrations of conjugated linoleic and trans fatty acids in milk fat from commercial dairy farms is associated with pasture and grazing management and supplementary feeding practices. Australian J. Exp. Agric. 48(8):1062-1075 (2008).
D'Urso S, Cutrignelli MI, Calabro S, Bovera F, Tudisco R, Piccolo V, Infascelli F. Influence of pasture on fatty acid profile of goat milk. J. Anim. Physiol. Anim. Nutr. 92(3):405-410 (2008).
Faucitano L, Chouinard PY, Fortin J, Mandell IB, Lafreniere C, Girard CL, Berthiaume R. Comparison of alternative beef production systems based on forage finishing or grain-forage diets with or without growth promotants: 2. Meat quality, fatty acid composition, and overall palatability. J. Anim. Sci. 86(7):1678-1689 (2008).
Felton DO, Ibrahim SA, AbuGhazaleh AA. Temporal changes in milk conjugated linoleic acid for cows fed a pasture- or conserved-forages-based diet and supplemented with fish oil and sunflower oil. Can. J. Anim. Sci. 88(1):123-127 (2008).
Ferlay A, Agabriel C, Sibra C, Journal C, Martin B, Chilliard Y. Tanker milk variability in fatty acids according to farm feeding and husbandry practices in a French semi-mountain area. Dairy Sci. Technol. 88(2):193-215 (2008).
Flowers G, Ibrahim SA, AbuGhazaleh AA. Milk fatty acid composition of grazing dairy cows when supplemented with linseed oil. J. Dairy Sci. 91(2):722-730 (2008).
Gama MAS, Gamsworthy PC, Griinari JM, Leme PR, Rodrigues PHM, Souza LWO, Lanna DPD. Diet-induced milk fat depression: Association with changes in milk fatty acid composition and fluidity of milk fat. Livestock Sci. 115(2-3):319-331 (2008).
Garcia PT, Pensel NA, Sancho AM, Latimori NJ, Kloster AM, Amigone MA, Casal JJ. Beef lipids in relation to animal breed and nutrition in Argentina. Meat Sci. 79(3):500-508 (2008).
Gill RK, VanOverbeke DL, Depenbusch B, Drouillard JS, DiCostanzo A. Impact of beef cattle diets containing corn or sorghum distillers grains on beef color, fatty acid profiles, and sensory attributes. J. Anim. Sci. 86(4):923-935 (2008).
Gomez-Cortes P, Frutos P, Mantecon AR, Juarez M, de la Fuente MA, Hervas G. Milk production, conjugated linoleic acid content, and in vitro ruminal fermentation in response to high levels of soybean oil in dairy ewe diet. J. Dairy Sci. 91(4):1560-1569 (2008).
Gomez-Cortes P, Frutos P, Mantecon AR, Juarez M, de la Fuente MA, Hervas G. Addition of olive oil to dairy ewe diets: Effect on milk fatty acid profile and animal performance. J. Dairy Sci. 91(8): 3119-3127 (2008).
Gorocica-Buenfil MA, Fluharty FL, Loerch SC. Effect of vitamin A restriction on carcass characteristics and immune status of beef steers. J. Anim. Sci. 86(7):1609-1616 (2008).
Gruffat D, Remond C, Durand D, Loreau O, Bauchart D. 9cis, 11trans conjugated linoleic acid (CLA) is synthesised and desaturated into conjugated 18 : 3 in bovine adipose tissues. Animal 2(4):645-652 (2008).
Juarez M, Horcada A, Alcalde MJ, Valera M, Mullen AM, Molina A. Estimation of factors influencing fatty acid profiles in light lambs. Meat Sci. 79(2):203-210 (2008).
Juchem SO, Santos JEP, Cerri RLA, Chebel RC, Galvao KN, Bruno R, Depeters EJ, Scottb T, Thatcher WW, Luchini D. Effect of calcium salts of fish and palm oils on lactational performance of Holstein cows. Anim. Feed Sci. Technol. 140(1-2):18-38 (2008).
Kadegowda AKG, Piperova LS, Erdman RA. Principal component and multivariate analysis of milk long-chain fatty acid composition during diet-induced milk fat depression. J. Dairy Sci. 91(2):749-759 (2008).
Kadegowda AKG, Piperova LS, Delmonte P, Erdman RA. Abomasal infusion of butterfat increases milk fat in lactating dairy cows. J. Dairy Sci. 91(6):2370-2379 (2008).
Khanal RC, Dhiman T, Boman RL. Changes in fatty acid composition of milk from lactating dairy cows during transition to and from pasture. Livestock Sci. 114(2-3):164-175 (2008).
Kim JH, Choi NJ, Park HG, Kim IH, Lee HG, Song MK, Whang KY, Kim YJ. Utilization of oil by-product from the purification process of conjugated linoleic acid as feeding supplements for the accumulation of conjugated linoleic acid in the egg yolk. Poultry Sci. 87(1):64-70 (2008).
Kim EJ, Huws SA, Lee MRF, Wood JD, Muetzel SM, Wallace RJ, Scollan ND. Fish oil increases the duodenal flow of long chain polyunsaturated fatty acids and trans-11 18 : 1 and decreases 18 : 0 in steers via changes in the rumen bacterial community. J. Nutr. 138(5):889-896 (2008).
King SS, AbuGhazaleh AA, Webel SK, Jones KL. Circulating fatty acid profiles in response to three levels of dietary omega-3 fatty acid supplementation in horses. J. Anim. Sci. 86(5):1114-1123 (2008).
Kucuk O, Hess BW, Rule DC. Fatty acid compositions of mixed ruminal microbes isolated from sheep supplemented with soybean oil. Res. Vet. Sci. 84(2):215-224 (2008). Diet
Kudrna V, Marounek M. Influence of feeding whole sunflower seed and extruded linseed on production of dairy cows, rumen and plasma constituents, and fatty acid composition of milk. Arch. Anim. Nutr. 62(1):60-69 (2008).
Latimori NJ, Kloster AM, Garcia PT, Carduza FJ, Grigioni G, Pensel NA. Diet and genotype effects on the quality index of beef produced in the Argentine Pampeana region. Meat Sci. 79(3):463-469 (2008).
Leiber F, Meier JS, Burger B, Wettstein HR, Kreuzer M, Hatt JM, Clauss M. Significance of coprophagy for the fatty acid profile in body tissues of rabbits fed different diets. Lipids 43(9):853-865 (2008).
Liu ZL, Yang DP, Chen P, Lin SB, Jiang XY, Zhao W, Li JM, Dong WX. Effect of dietary sources of roasted oilseeds on blood parameters and milk fatty acid composition. Czech J. Anim. Sci. 53(5)219-226 (2008).
Lourenco M, Van Ranst G, Vlaeminck B, De Smet S, Fievez V. Influence of different dietary forages on the fatty acid composition of rumen digesta as well as ruminant meat and milk. Anim. Feed Sci. Technol. 145(1-4):418-437 (2008).
Lucas A, Coulon JB, Agabriel C, Chilliard Y, Rock E. Relationships between the conditions of goat's milk production and the contents of some components of nutritional interest in Rocamadour cheese. Small Ruminant Res. 74(1-3):91-106 (2008).
Luna P, Bach A, Juarez M, de la Fuente MA. Effect of a diet enriched in whole linseed and sunflower oil on goat milk fatty acid composition and conjugated linoleic acid isomer profile. J. Dairy Sci. 91(1):20-28 (2008).
Luna P, Bach A, Juarez M, de la Fuente MA. Influence of diets rich in flax seed and sunflower oil on the fatty acid composition of ewes' milk fat especially on the level of conjugated linoleic acid, n-3 and n-6 fatty acids. Internat. Dairy J. 18(1):99-107 (2008).
Martin D, Muriel E, Antequera T, Perez-Palacios T, Ruiz J. Fatty acid composition and oxidative susceptibility of fresh loin and liver from pigs fed conjugated linoleic acid in combination with monounsaturated fatty acids. Food Chem. 108(1):86-96 (2008).
Mel'uchova B, Blasko J, Kubinec R, Gorova R, Dubravska J, Margetin M, Sojak L. Seasonal variations in fatty acid composition of pasture forage plants and CLA content in ewe milk fat. Small Ruminant Res. 78(1-3):56-65 (2008).
Moate PJ, Chalupa W, Boston RC, Lean IJ. Milk fatty acids II: Prediction of the production of individual fatty acids in bovine milk. J. Dairy Sci. 91(3):1175-1188 (2008).
Moreno T, Keane MG, Noci F, Moloney AP. Fatty acid composition of M-Longissimus dorsi from Holstein-Friesian steers of New Zealand and European/American descent and from Belgian Blue x Holstein-Friesian steers, slaughtered at two weights/ages. Meat Sci. 78(3):157-169 (2008).
Murphy JJ, Coakley M, Stanton C. Supplementation of dairy cows with a fish oil containing supplement and sunflower oil to increase the CLA content of milk produced at pasture. Livestock Sci. 116(1-3):332-337 (2008).
Nelson ML, Busboom JR, Ross CF, O'Fallon JV. Effects of supplemental fat on growth performance and quality of beef from steers fed corn finishing diets. J. Anim. Sci. 86(4):936-948 (2008).
Niedzwiedzka KM, Kowalczyk J, Czauderna M. Influence of selenate and linseed oil on fatty-acid and amino-acid profiles in the liver, muscles, fat tissues and blood plasma of sheep. J. Anim. Feed Sci. 17(3):328-343 (2008).
Nuernberg K, Fischer A, Nuernberg G, Ender K, Dannenberger D. Meat quality and fatty acid composition of lipids in muscle and fatty tissue of Skudde lambs fed grass versus concentrate. Small Ruminant Res. 74(1-3):279-283 (2008).
Oliveira RL, Ladeira MM, Barbosa MAAF, Assuncao DMP, Matsushita M, Santos GT, Oliveira RL. Linoleic conjugated acid and fatty acids profile in the muscle and fat layer of water buffalo steers fed different sources. Arqquivo Brasileiro Medicina Veterinaria Zootecnia 60(1):169-178 (2008).
Or-Rashid MM, Kramer JKG, Wood MA, McBride BW. Supplemental algal meal alters the ruminal trans-18 : 1 fatty acid and conjugated linoleic acid composition in cattle. J. Anim. Sci. 86(1):187-196 (2008).
Osborne VR, Radhakrishnan S, Odongo NE, Hill AR, McBride BW. Effects of supplementing fish oil in the drinking water of dairy cows on production performance and milk fatty acid composition. J. Anim. Sci. 86(3):720-729 (2008).
Paradis C, Berthiaume R, Lafreniere C, Gervais R, Chouinard PY. Conjugated linoleic acid content in adipose tissue of calves suckling beef cows on pasture and supplemented with raw or extruded soybeans. J. Anim. Sci. 86(7):1624-1636 (2008).
Prado IN, Ito RH, Prado JM, Prado IM, Rotta PP, Matsushita M, Visentainer JV, Silva RR. The influence of dietary soyabean and linseed on the chemical composition and fatty acid profile of the Longissimus muscle of feedlot-finished bulls. J. Anim. Feed Sci. 17(3):307-317 (2008).
Raminowicz RH, Krewer M, Leuenberger H, Scheeder MRL. Efficiency of extruded linseed for the finishing of grass-fed steers to counteract a decline of omega-3 fatty acids in the beef. Livestock Sci. 114(2-3):150-163 (2008).
Rego OA, Regalo SMM, Rosa HJD, Alves SP, Borba AES, Bessa RJB, Cabrita ARJ, Fonseca AJM. Effects of grass silage and soybean meal supplementation on milk production and milk fatty acid profiles of grazing dairy cows. J. Dairy Sci. 91(7): 2736-2743 (2008).
Rego OA, Rosa HJD, Regalo SM, Alves SP, Alfaia CMM, Prates JAM, Vouzelal CM, Bessal RJB. Seasonal changes of CLA isomers and other fatty acids of milk fat from grazing dairy herds in the Azores. J. Sci. Food Agric. 88(10):1855-1859 (2008).
Sahana J, Oudshoorn FW, Larsen T, Nielsen JH, Weisbjerg MR, Kristensen T. Milk composition as affected by time limited grazing combined with restricted indoor feeding. Milk Sci. Internat. 63(3):235-238 (2008).
Sasikala-Appukuttan AK, Schingoethe DJ, Hippen AR, Kalscheur KF, Karges K, Gibson ML. The feeding value of corn distillers solubles for lactating dairy cows. J. Dairy Sci. 91(1):279-287 (2008).
Schmidt J, Husveth F, Sipocza J, Toth T, Fabian J. Dietary manipulations to increase the concentration of conjugated linoleic acid in milk. Acta Alimentaria 37(1):53-63 (2008).
Shingfield KJ, Arola A, Ahvenjarvi S, Vanhatalo A, Toivonen V, Griinari JM, Huhtanen P. Ruminal infusions of cobalt-EDTA reduce mammary Delta 9-desaturase index and alter milk fatty acid composition in lactating cows. J. Nutr. 138(4):710-717 (2008).
Suksombat W, Chullanandana K. Effects of soybean oil or rumen protected conjugated linoleic acid supplementation on accumulation of conjugated linoleic acid in dairy cows' milk. Asian-Australian J. Anim. Sci. 21(9):1271-1277 (2008).
Suksombat W, Chullanandana K. Effects of soybean oil or whole cotton seed addition on accumulation of conjugated linoleic acid in beef of fattening BrahmanxThai-Native cattle. Asian-Australasian J. Anim. Sci. 21(10):1458-1465 (2008).
Sultana H, Ishida T, Shintaku T, Kanda S, Itabashi H. Effect of feeding Ca-salts of fatty acids from soybean oil and linseed oil on c9,t11-CLA production in ruminal fluid and milk of Holstein dairy cows. Asian-Australian J. Anin. Sci. 21(9):1262-1270 (2008).
Tsiplakou E, Kominakis A, Zervas G. The interaction between breed and diet on CLA and fatty acids content of milk fat of four sheep breeds kept indoors or at grass. Small Ruminant Res. 74(1-3):179-187 (2008).
Tsiplakou E, Zervas G. The effect of dietary inclusion of olive tree leaves and grape marc on the content of conjugated linoleic acid and vaccenic acid in the milk of dairy sheep and goats. J. Dairy Res. 75(3):270-278 (2008).
Uccioni AB, Antongiovanni M, Petacchi F, Mele M, Serra A, Secchiari P, Minieri S. Effect of dried or green herbage on vaccenic acid and conjugated linoleic acid production during in vitro rumen fermentation. Anim. Feed Sci. Technol. 140(1-2):207-213 (2008).
Van QCD, Focant M, Deswysen D, Mignolet E, Turu C, Pottier I, Froidmont E, Larondelle Y. Influence of an increase in diet structure on milk conjugated linoleic acid content of cows fed extruded linseed. Animal 2(10):1538-1547 (2008).
Van Dorland HA, Kreuzer M, Leuenberger H, Wettstein HR . Comparative potential of white and red clover to modify the milk fatty acid profile of cows fed ryegrass-based diets from zero-grazing and silage systems. J. Sci. Food Agric. 88(1):77-85 (2008).
Varadyova Z, Kisidayova S, Siroka P, Jalc D. Comparison of fatty acid composition of bacterial and protozoal fractions in rumen. fluid of sheep fed diet supplemented with sunflower, rapeseed and linseed Oils. Anim. Feed Sci. Technol. 144(1-2):44-54 (2008).
Warren HE, Scollan ND, Enser M, Hughes SI, Richardson RI, Wood JD. Effects of breed and a concentrate or grass silage diet on beef quality in cattle of 3 ages. I: Animal performance, carcass quality and muscle fatty acid composition. Meat Sci. 78(3):256-269 (2008).
Wyss U, Collomb M. Influence of temporary and permanent grassland on milk fat composition. Rev. Suisse d’Agriculture 40(1):46-50 (2008).
Yu LL, Wang RL, Zhang YZ, Kleemann DO, Zhu XP, Jia ZH. Effects of selenium supplementation on polyunsaturated fatty acid concentrations and antioxidant status in plasma and liver of lambs fed linseed oil or sunflower oil diets. Anim. Feed Sci. Technol. 140(1-2):39-51 (2008).
Zunong M, Hanada M, Aibibula Y, Okamoto M, Tanaka K. Variations in conjugated linoleic acid concentrations in cows milk, depending on feeding systems in different seasons. Asian-Australasian J. Anim. Sci. 21(10):1466-1472 (2008).

Food, CLA levels in return to top

Costa P, Roseiro LC, Bessa RJB, Padilha M, Partidario A, de Almeida JM, Calkins CR, Santos C. Muscle fiber and fatty acid profiles of Mertolenga-PDO meat. Meat Sci. 78(4):502-512 (2008).
Ekinci FY, Okur OD, Ertekin B, Guzel-Seydim Z. Effects of probiotic bacteria and oils on fatty acid profiles of cultured cream. European J. Lipid Sci. Technol. 110(3)216-224 (2008).
Garcia PT, Casal JJ, Fianuchi S, Magaldi JJ, Rodriguez FJ, Nancucheo JA. Conjugated linoleic acid (CLA) and polyunsaturated fatty acids in muscle lipids of lambs from the Patagonian area of Argentina. Meat Sci. 79(3):541-548 (2008).
Jimenez M, Garcia HS, Beristain CI. Sensory evaluation of dairy products supplemented with microencapsulated conjugated linoleic acid (CLA). LWT-Food Sci. Technol. 41(6):1047-1052 (2008).
Kraft J, Kramer JKG, Schoene F, Chambers JR, Jahreis G. Extensive analysis of long-chain polyunsaturated fatty acids, CLA, trans-18 : 1 isomers, and plasmalogenic lipids in different retail beef types. J. Agric. Food Chem. 56(12):4775-4782 (2008).
Liu TT, Yang TS. Effects of water-soluble natural antioxidants on photosensitized oxidation of conjugated linoleic acid in an oil-in-water emulsion system. J. Food Sci. 73(4): C256-C261 (2008).
Mendis S, Cruz-Hernandez C, Ratnayake WMN. Fatty acid profile of Canadian dairy products with special attention to the trans-octadecenoic acid and conjugated linoleic acid isomers. J. AOAC Internat. 91(4):811-819 (2008).
Or-Rashid MM, Odongo NE, Subedi B, Karki P, McBride BW. Fatty acid composition of yak (Bos grunniens) cheese including conjugated linoleic acid and trans-18 : 1 fatty acids. J. Agric. Food Chem. 56(5):1654-1660 (2008).
Park SY, Aw JE, Kim GB, Jung MY, Lee BH. Distribution and content of geometric isomers of conjugated linoleic acid in dairy foods from the Quebec province of Canada. Food Sci. Technol. 17(1):31-37 (2008).
Rehberger B, Butikofer U, Bisig W, Collomb M. Influence of a dry fractionation of butterfat on the content of fatty acids including conjugated linoleic acids. European Food Res. Technol. 226(3):627-632 (2008).
Schievano E, Pasini G, Cozzi G, Mammi S. Identification of the production chain of Asiago d'Allevo cheese by nuclear magnetic resonance spectroscopy and principal component analysis. J. Agric. Food Chem. 56(16):7208-7214 (2008).
Schone F, Jahreis G, Steinhart H, Jahn O, Leiterer M, Wassmuth R, Greiling A, Hartung H, Kinast C. Beef provenances in quality test - Meat properties, sensory ranking, microbial status and nutrition-relevant constituents. Deutsche Lebensm.-Rundschau 104(7):319-330 (2008).
Shingfield KJ, Chilliard Y, Toivonen V, Kairenius P, Givens DI. Trans fatty acids and bioactive lipids in ruminant milk. Bioactive Components Milk 606:3-65 (2008).
Sierra V, Aldai N, Castro P, Osoro K, Coto-Montes A, Olivan M. Prediction of the fatty acid composition of beef by near infrared transmittance spectroscopy. Meat Sci. 78(3):248-255 (2008).

General Articles and Reviews return to top

Candow DG. The impact of nutritional and exercise strategies for aging bone and muscle. Appl. Physiol. Nutr. Metab. 33(1):181-183 (2008).
Gereszek LJ, Coats JR, Beitz DC. Effects of dietary conjugated linoleie acid on European corn borer (Lepidoptera : Crambidae) survival, fatty acid profile, and fecundity. Ann. Entomological Soc. Am. 101(2):430-438 (2008).
Li JJ, Huang CJ, Xie D. Anti-obesity effects of conjugated linoleic acid, docosahexaenoic acid, and eicosapentaenoic acid. (Review.) Molec. Nutr. Food Res. 52(6):631-645 (2008).
Milanesi E, Nicoloso L, Crepaldi P. Stearoyl CoA desaturase (SCD) gene polymorphisms in Italian cattle breeds. J. Anim. Breeding Genetics 125(1):63-67 (2008).
Nagao K, Yanagita T. Bioactive lipids in metabolic syndrome. Progress Lipid Res. 47(2):127-146 (2008).
Pajunen TI, Koskela H, Hase T, et al. NMR properties of conjugated linoleic acid (CLA) methyl ester hydroperoxides. Chem. Physics Lipids 154(2):105-114 (2008).
Park JHY. Inhibition of colon cancer cell growth by dietary components: role of the insulin-like growth factor (IGF) system. Asia Pacific J. Clin. Nutr. 17:257-260 (Suppl. 1) (2008).
Plourde M, Jew S, Cunnane SC, Jones PJH. Conjugated linoleic acids: why the discepancy between animal and human studies? (Review.) Nutr. Rev. 66(7):415-421 (2008).
Santos-Zago LF, Botelho AP, de Oliveira AC. Effects of conjugated linoleic acid on animal metabolism: advances in research and perspectives for the future. Brazilian J. Nutr. 21(2):195-221 (2008).
Soyeurt H, Gengler N. Genetic variability of fatty acids in bovine milk. Biotechnol. Agronomie Soc. Environ. 12(2):203-210 (2008).
Steijns JM. Dairy products and health: Focus on their constituents or on the matrix? Internat. Dairy J. 18(5):425-435 (2008).
Wallace RJ. Gut microbiology - broad genetic diversity, yet specific metabolic niches. Animal 2(5):661-668 (2008).
Webb EC, O'Neill HA. The animal fat paradox and meat quality. Meat Sci. 80(1):28-36 (2008).
Wood JD, Enser M, Fisher AV, Nute GR, Sheard PR, Richardson RI, Hughes SI, Whittington FM. Fat deposition, fatty acid composition and meat quality: A review. Meat Sci. 78(4):343-358 (2008).

Physiological Effects of CLA in Humans return to top

Cherniack EP. Potential applications for alternative medicine to treat obesity in an aging population. Alternative Med. Rev. 13(1):34-42 (2008).
Diaz ML, Watkins BA, Li Y, Anderson RA, Campbell WW. Chromium picolinate and conjugated linoleic acid do not synergistically influence diet- and exercise-induced changes in body composition and health indexes in overweight women. J. Nutr. Biochem. 19(1):61-68 (2008).
Motard-Belanger A, Charest A, Grenier G, Paquin P, Chouinard Y, Lemieux S, Couture P, Lamarche B. Study of the effect of trans fatty acids from ruminants on blood lipids and other risk factors for cardiovascular disease. Am. J. Clin. Nutr. 87(3):593-599 (2008).
Moutsioulis AA, Rule DC, Murrieta CM, Bauman DE, Lock AL, Barbano DM, Carey GB. Human breast milk enrichment in conjugated linoleic acid after consumption of a conjugated linoleic acid-rich food product: a pilot study. Nutr. Res. 28(7):437-442 (2008).
Sneddon AA, Tsofliou F, Fyfe CL, Matheson I, Jackson DM, Horgan G, Winzell MS, Wahle KWJ, Ahren B, Williams LM. Effect of a conjugated linoleic acid and omega-3 fatty acid mixture on body composition and adiponectin. Obesity 16(5):1019-1024 (2008).
Tarnopolsky MA, Safdar A. The potential benefits of creatine and conjugated linoleic acid as adjuncts to resistance training in older adults. Appl. Physiol. Nutr. Metab. 33(1):213-227 (2008).
Tholstrup T, Raff M, Straarup EM, Lund P, Basu S, Bruun JM. An oil mixture with trans-10, cis-12 conjugated linoleic acid increases markers of inflammation and in vivo lipid peroxidation compared with cis-9, trans-11 conjugated linoleic acid in postmenopausal women. J. Nutr. 138(8):1445-1451 (2008).
Turpeinen AA, Ylonen N, von Willebrand E, Basu S, Aro A. Immunological and metabolic effects of cis-9, trans-11-conjugated linoleic acid in subjects with birch pollen allergy. Brit. J. Nutr. 100(1):112-119 (2008).

Physiological Effects of CLA in Animals: Laboratory Animals, Companion Animals return to top

Banu J, Bhattacharya A, Rahman M, Fernandes G. Beneficial effects of conjugated linoleic acid and exercise on bone of middle-aged female mice. J. Bone Mineral Metab. 26(5):436-445 (2008).
Bissonauth V, Chouinard PY, Marin J, Leblanc N, Richard D, Jacques H. Altered lipid response in hamsters fed cis-9,trans-11+trans-8,cis-10 conjugated linoleic acid mixture. Lipids 43(3):251-258 (2008).
Botelho AP, Santos-Zago LF, de Oliveira AC. Conjugated linoleic acid supplementation modified the body composition and serum leptin levels in weaning rats. Archivos Latinoamericanos Nutricion 58(2):156-163 (2008).
Diniz YS, Santos PP, Assalin HB, Souza GA, Rocha KKHR, Ebaid GMX, Seiva FRF, Amauchi JF, Novelli Filho JLVB, Novelli ELB. Conjugated linoleic acid and cardiac health: Oxidative stress and energetic metabolism in standard and sucrose-rich diets. European J. Pharmacol. 579(1-3):318-325 (2008).
Ferramosca A, Savy V, Conte L, Zara V. Dietary combination of conjugated linoleic acid (CLA) and pine nut oil prevents CLA-induced fatty liver in mice. J. Agric. Food Chem. 56(17):8148-8158 (2008).
Iqbal MJ, Higginbotham A, Chickris N, Bollaert M, Rockway S, Banz WJ. A combination of a CLA-DAG oil modifies the diabetic phenotype in male Zucker diabetic fatty rats. Hormone Metabolic Res. 40(4):262-268 (2008).
Jaudszus A, Krokowski M, Mockel P, Darcan Y, Avagyan A, Matricardi P, Jahreis G, Hamelmann E. Cis-9,trans-11-conjugated linoleic acid inhibits allergic sensitization and airway inflammation via a PPAR gamma-related mechanism in mice. J. Nutr. 138(7):1336-1342 (2008).
Kanwar RK, MacGibbon AK, Black PN, Kanwar JR, Rowan A, Vale M, Krissansen GW. Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic airway disease in mice. Clin. Exp. Allergy 38(1):208-218 (2008).
Liao CF, Shaw HM, Chao PM. Impairment of glucose metabolism in mice induced by dietary oxidized frying oil is different from that induced by conjugated linoleic acid. Nutrition 24(7-8):744-752 (2008).
Lopes PA, Martins SV, Pinho MS, Alfaia CM, Fontes CMGA, Rodrigues PO, Morais GSL, Castro MF , Pinto R, Prates JAM . Diet supplementation with the cis-9,trans-11 conjugated linoleic acid isomer affects the size of adipocytes in Wistar rats. Nutr. Res. 28(7):480-486 (2008).
Louw L, Claassen A. HPV-induced recurrent laryngeal papillomatosis: rationale for adjuvant fatty acid therapy. Asia Pacific J. Clin. Nutr. 17(2):187-193 (2008).
Mandir N, Goodlad RA. Conjugated linoleic acids differentially alter polyp number and diameter in the Apc(min/+) mouse model of intestinal cancer. Cell Proliferation 41(2):279-291 (2008).
Meng XJ, Shoemaker SF, Mcgee SO, Ip MM. t10,c12-Conjugated linoleic acid stimulates mammary tumor progression in Her2/ErbB2 mice through activation of both proliferative and survival pathways. Carcinogenesis 29(5):1013-1021 (2008).
Nunes EA, Bonatto SJ, de Oliveira HHP, Rivera NLM, Maiorka A, Krabbe EL, Tanhoffer RA , Fernandes LC. The effect of dietary supplementation with 9-cis : 12-trans and 10-trans : 12-cis conjugated linoleic acid (CLA) for nine months on serum cholesterol, lymphocyte proliferation and polymorphonuclear cells function in Beagle dogs. Res. Veterinary Sci. 84(1):62-67 (2008).
Ogborn MR, Nitschmann E, Goldberg A, Bankovic-Calic N, Weiler HA, Aukema HM. Dietary conjugated linoleic acid renal benefits and possible toxicity vary with isomer, dose and gender in rat polycystic kidney disease. Lipids 43(9):783-791 (2008).
Ruth MR, Taylor CG, Zahradka P, Field CJ. Abnormal immune responses in fa/fa Zucker rats and effects of feeding conjugated linoleic acid. Obesity 16(8):1770-1779 (2008).
Sikorski AM, Hebert N, Swain RA. Conjugated Linoleic Acid (CLA) inhibits new vessel growth in the mammalian brain. Brain Res. 1213:35-40 (2008).
Tardy AL, Giraudet C, Rousset P, Rigaudiere JP, Laillet B, Chalancon S, Salles J, Loreau O, Chardigny JM, Morio B. Effects of trans MUFA from dairy and industrial sources on muscle mitochondrial function and insulin sensitivity. J. Lipid Res. 49(7):1445-1455 (2008).
Wendel AA, Purushotham A, Liu LF, Belury MA. Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice. J. Lipid Res. 49(1):98-106 (2008).
Yanagita T, Nagao K. Functional lipids and the prevention of the metabolic syndrome. Asia Pacific J. Clin. Nutr. 17:189-191 (Suppl. 1) (2008).
Zhou XR, Sun CH, Liu JR, Zhao D. Dietary conjugated linoleic acid increases PPAR gamma gene expression in adipose tissue of obese rat, and improves insulin resistance. Growth Hormone IGF Res. 18(5):361-368 (2008).

Physiological Effects of CLA in Animals: Food/Farm Animals return to top

Bauman DE, Perfield JW, Harvatine KJ, Baumgard LH. Regulation of fat synthesis by conjugated linoleic acid: Lactation and the ruminant model. J. Nutr. 138(2):403-409 (2008).
Cachaldora P, Garia-Rebollar P, Alvarez C, Mendez J, De Blas JC. Double enrichment of chicken eggs with conjugated linoleic acid and n-3 fatty acids through dietary fat supplementation. Anim. Feed Sci. Technol. 144(3-4):315-326 (2008).
Corino C, Musella M, Pastorelli G, Rossi R, Paolone K, Costanza L, Manchisi A, Maiorano G. Influences of dietary conjugated linoleic acid (CLA) and total lysine content on growth, carcass characteristics and meat quality of heavy pigs. Meat Sci. 79(2):307-316 (2008).
Fernandez-Figares I, Conde-Aguilera JA, Nieto R, Lachica M (Lachica, M.), Aguilera JF. Synergistic effects of betaine and conjugated linoleic acid on the growth and carcass composition of growing Iberian pigs. J. Anim. Sci. 86(1):102-111 (2008).
Gervais R, Chouinard PY. Effects of intravenous infusion of conjugated diene 18 : 3 isomers on milk fat synthesis in lactating dairy cows. J. Dairy Sci. 91(9):3568-3578 (2008).
Huang Y, Schoonmaker JP, Bradford BJ, Beitz DC. Response of milk fatty acid composition to dietary supplementation of soy oil, conjugated linoleic acid, or both. J. Dairy Sci. 91(1):260-270 (2008).
Janz JAM, Morel PCH, Purchas RW, Corrigan VK, Cumarasamy S, Wilkinson BHP, Hendriks WH. The influence of diets supplemented with conjugated linoleic acid, selenium, and vitamin E, with or without animal protein, on the quality of pork from female pigs. J. Anim. Sci. 86(6):1402-1409 (2008).
Jose AAFBV, Gama MAS, Lanna DDP. Effects of trans-10, cis-12 conjugated linoleic acid on gene expression and lipid metabolism of adipose tissue of growing pigs. Genetics Molec. Res. 7(2):284-294 (2008).
Kim YJ, Yoon YB. Effects of various levels of conjugated linoleic acid supplementation on the quality of chicken meat. Korean J. Food Sci. Anim. Res. 28(3):251-255 (2008).
Konig B, Spielmann J, Haase K, Brandsch C, Kluge H, Stangl GI, Eder K. Effects of fish oil and conjugated linoleic acids on expression of target genes of PPAR alpha and sterol regulatory element-binding proteins in the liver of laying hens. Brit. J. Nutr. 100(2):355-363 (2008).
Lock AL, Rovai M, Gipson TA, de Veth MJ, Bauman DE. A conjugated linoleic acid supplement containing trans-10, cis-12 conjugated linoleic acid reduces milk fat synthesis in lactating goats. J. Dairy Sci. 91(9):3291-3299 (2008).
Marounek M, Skrivanova V, Vyborna A, Duskova D. Performance and tissue fatty acid profiles in veal calves fed diets supplemented with conjugated linoleic acids. Arch. Anim. Nutr. 62(5):366-376 (2008).
Martin D, Antequera T, Muriel E, Andres AI, Ruiz J. Oxidative changes of fresh loin from pig, caused by dietary conjugated linoleic acid and monounsaturated fatty acids, during refrigerated storage. Food Chem. 111(3):730-737 (2008).
Martin D, Muriel E, Gonzalez E, Viguera J, Ruiz J. Effect of dietary conjugated linoleic acid and monounsaturated fatty acids on productive, carcass and meat quality traits of pigs. Livestock Sci. 117(2-3):155-164 (2008).
Morel PCH, Janz JAM, Zou M, Purchas RW, Hendriks WH, Wilkinson BHP. The influence of diets supplemented with conjugated linoleic acid, selenium, and vitamin E, with or without animal protein, on the composition of pork from female pigs. J. Anim. Sci. 86(5):1145-1155 (2008).
Nagao K, Inoue N, Ujino Y, Higa K, Shirouchi B, Wang YM, Yanagita T. Effect of leptin infusion on insulin sensitivity and lipid metabolism in diet-induced lipodystrophy model mice. Lipids Health Dis. 7: art. 8 (2008).
Patterson R, Connor ML, Krause DO, Nyachoti CM. Response of piglets weaned from sows fed diets supplemented with conjugated linoleic acid (CLA) to an Escherichia coli K88(+) oral challenge. Animal 2(9):1303-1311 (2008).
Pereira RM, Carvalhais I, Pimenta J, Baptista MC, Vasques MI, Horta AEM, Santos IC, Marques MR, Reis A, Pereira MS, Marques CC. Biopsied and vitrified bovine embryos viability is improved by trans10, cis12 conjugated linoleic acid supplementation during in vitro embryo culture. Anim. Reproduction Sci. 106(3-4):322-332 (2008).
Ramos A, Bandarra NM, Rema P, Vaz-Pires P, Nunes ML, Andrade AM, Cordeiro AR, Valente LMP. Time course deposition of conjugated linoleic acid in market size rainbow trout (Oncorhynchus mykiss) muscle. Aquaculture 274(2-4):366-374 (2008).
Schmid A, Collomb M, Bee G, Butikofer U, Wechsler D, Eberhard P, Sieber R. Effect of dietary alpine butter rich in conjugated linoleic acid on milk fat composition of lactating sows. Brit. J. Nutr. 100(1):54-60 (2008).
Yin JD, Shang XG, Li DF, Wang FL, Guan YF, Wang ZY. Effects of dietary conjugated linoleic acid on the fatty acid profile and cholesterol content of egg yolks from different breeds of layers. Poultry Sci. 87(2):284-290 (2008).
Zhang HJ, Tian YD, Guo YM, Yuan JM. Dietary conjugated linoleic acid improves antioxidant capacity in broiler chicks. Brit. Poultry Sci. 49(2):213-221 (2008).
Zhang XH, Wang BW, Wang L, Long FY, Yang ZG, Yu SH, Wang YC, Wei XX, Jing LZ, Liu GL. Effect of dietary conjugated linoleic acid (CLA) on the growth and lipid metabolism of geese and fatty acid composition of their tissues. South African J. Anim. Sci. 38(1)12-20 (2008).
Zhao ZY, Wu TX, Tang HG, Zhang JZ. Influence of dietary conjugated linoleic acid on growth, fatty acid composition and hepatic lipogenesis in large yellow croaker (Pseudosciaena crocea R.). J. Zhejiang Univ. Sci. B 9(9):691-700 (2008).

Physiological Effects of CLA in Cell Cultures / In Vitro Studies return to top

Alibin CP, Kopilas MA, Anderson HDI. Suppression of cardiac myocyte hypertrophy by conjugated linoleic acid - Role of peroxisome proliferator-activated receptors alpha and gamma. J. Biol. Chem. 283(16):10707-10715 (2008).
Benedetti E, Galzio R, Cinque B, Biordi L, D'Amico MA, D'Angelo B, Laurenti G, Ricci A, Festuccia C, Cifone MG, Lombardi D, Cimini A. Biomolecular characterization of human glioblastoma cells in primary cultures: Differentiating and antiangiogenic effects of natural and synthetic PPAR gamma agonists. J. Cell. Physiol. 217(1):93-102 (2008).
Bergamo P, Maurano F, D'Arienzo R, David C, Rossi M. Association between activation of phase 2 enzymes and down-regulation of dendritic cell maturation by c9,t11-conjugated linoleic acid. Immunol. Lett. 117(2):181-190 (2008).
Cho MH, Kang JH, Yang MP. Immunoenhancing effect of trans-10, cis-12 conjugated linoleic acid on the phagocytic capacity and oxidative burst activity of canine peripheral blood phagocytes. Res. Vet. Sci. 85(2):269-278 (2008).
Fagali N, Catala A. Antioxidant activity of conjugated linoleic acid isomers, linoleic acid and its methyl ester determined by photoemission and DPPH center dot techniques. Biophysical Chem. 137(1):56-62 (2008).
Goua M, Mulgrew S, Frank J, Rees D, Sneddon AA, Wahle KWJ . Regulation of adhesion molecule expression in human endothelial and smooth muscle cells by omega-3 fatty acids and conjugated linoleic acids: Involvement of the transcription factor NF-kappa B? Prostaglandins Leukotrienes Essential Fatty Acids 78(1):33-43 (2008).
Iassonova DR, Hammond EG, Beattie SE. Oxidative stability of polyunsaturated triacylglycerols encapsulated in oleaginous yeast. J. Am. Oil Chem. Soc. 85(8):711-716 (2008).
Islam MA, Kim YS, Jang WJ, Lee SA, Kim HG, Kim SY, Kim JO, Ha YL. A mixture of trans, trans conjugated linoleic acid induces apoptosis in MCF-7 human breast cancer cells with reciprocal expression of Bax and Bcl-2. J. Agric. Food Chem. 56(14):5970-5976 (2008).
Kang JH, Yang MP. In vitro evaluation of the effect of trans-10, cis-12 conjugated linoleic acid on phagocytosis by canine peripheral blood polymorphonuclear neutrophilic leukocytes exposed to methylprednisolone sodium succinate. Am. J. Vet. Res. 69(4):494-500 (2008).
Kim YS, Cerbo RM, Hah CK, Bahn KN, Kim JO, Ha YL. Growth inhibition of osteosarcoma cell MG-63 by a mixture of trans,trans conjugated linoleic acid isomers: Possible mechanistic actions. J. Food Sci. 73(1):T7-T15 (2008).
Larsen AE, Cameron-Smith D, Crowe TC. Conjugated linoleic acid suppresses myogenic gene expression in a model of human muscle cell inflammation. J. Nutr. 138(1):12-16 (2008).
Miller JR, Siripurkpong P, Hawes J, Majdalawieh A, Ro HS, McLeod RS. The trans-10, cis-12 isomer of conjugated linoleic acid decreases adiponectin assembly by PPAR gamma-dependent and PPAR gamma-independent mechanisms. J. Lipid Res. 49(3):550-562 (2008).
Moon HS, Lee HG, Seo JH, Guo DD, Kim IY, Chung CS , Kim TG, Choi YJ, Cho CS. Lipolysis is stimulated by PEGylated conjugated linoleic acid through the cyclic adenosine monophosphate-independent signaling pathway in 3T3-L1 cells: Activation of MEK/ERK MAPK signaling pathway and hyper-secretion of adipo-cytokines. J. Cell. Physiol. 214(2):283-294 (2008).
Nie L, Ren Y, Janakiraman A, Smith S, Schulz H. A novel paradigm of fatty acid beta-oxidation exemplified by the thioesterase-dependent partial degradation of conjugated linoleic acid that fully supports growth of Escherichia coli. Biochemistry 47(36):9618-9626 (2008).
Ou LH, Wu Y, Ip C, Meng XJ, Hsu YC, Ip MM. Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response. J. Lipid Res. 49(5):985-994 (2008).
Pajunen TI, Johansson MP, Hase T, Hopia A. Autoxidation of conjugated linoleic acid methyl ester in the presence of alpha-tocopherol: The hydroperoxide pathway. Lipids 43(7):599-610 (2008).
Peter A, Weigert C, Staiger H, Rittig K, Cegan A, Lutz P, Machicao F, Haring HU, Schleicher E. Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity. Am. J. Physiol. Endocrinol. Metab. 295(2):E339-E349 (2008).
Reynolds CM, Loscher CE, Moloney AP, Roche HM . Cis-9, trans-11-conjugated linoleic acid but not its precursor trans-vaccenic acid attenuate inflammatory markers in the human colonic epithelial cell line Caco-2. Brit. J. Nutr. 100(1):13-17 (2008).
Ringseis R, Gahler S, Eder K. Conjugated linoleic acid isomers inhibit platelet-derived growth factor-induced NF-kappa B transactivation and collagen formation in human vascular smooth muscle cells. European J. Nutr. 47(2):59-67 (2008).
Ringseis R, Schulz N, Saal D, Eder K . Troglitazone but not conjugated linoleic acid reduces gene expression and activity of matrix-metalloproteinases-2 and -9 in PMA-differentiated THP-1 macrophages. J. Nutr. Biochem. 19(9):594-603 (2008).
Stachowska E, Baskiewicz-Masiuk M, Dziedziejko V, Gutowska L, Baranowska-Bosiacka I, Marchlewicz M, Dolegowska B, Wiszniewska B, Machalinski B, Chlubek D. Conjugated linoleic acid increases intracellular ROS synthesis and oxygenation of arachidonic acid in macrophages. Nutrition 24(2):187-199 (2008).
Viswanadha S, McGilliard ML, Gandour RD, Herbein JH. Alterations in CPT-1 mRNA and fatty acid profile in hepatic cell lines in response to treatment with t10,c12-or c9,t11-conjugated linoleic acid. European J. Lipid Sci. Technol. 110(1):16-22 (2008).
Wang LS, Huang YW, Liu S, Yan P, Lin YC. Conjugated linoleic acid induces apoptosis through estrogen receptor alpha in human breast tissue. BMC Cancer 8, Article Number: 208 (2008).
Yamasaki M, Tachibana H, Yamada A, Ochi Y, Madhyastha H, Nishiyama K, Yamada K. Oleic acid prevents apoptotic cell death induced by trans10, cis12 isomer of conjugated linoleic acid via p38 MAP kinase dependent pathway. In Vitro Cellular Developmental Biol. Animal 44(7):290-294 (2008).
Yee JK, Mao CS, Hummel HS, Lim S, Sugano S, Rehan VK, Xiao G, Lee WNP. Compartmentalization of stearoyl-coenzyme A desaturase 1 activity in HepG2 cells. J. Lipid Res. 49(10):2124-2134 (2008).

Synthesis and Degradation: In vitro, Microbial, and Plant return to top

Adamczak M, Bornscheuer UT, Bednarski W. Properties and biotechnological methods to produce lipids containing conjugated linolleic acid. (Review.) European J. Lipid Sci. Technol. 110(6):491-504 (2008).
Alim MA, Lee JH, Akoh CC, Choi MS, Jeon MS, Shin JA, Lee KT. Enzymatic transesterification of fractionated rice bran oil with conjugated linoleic acid: Optimization by response surface methodology. LWT Food Sci. Technol. 41(5)764-770 (2008).
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